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This timeline traces the development of DNA profiling from Alec Jeffreys’s pioneering discovery of genetic fingerprinting to its widespread use in forensic science, criminal investigations, paternity testing, and identification. More Less
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Part of our collection of science timelines.
1981
Jeffrey Glassberg carried out work at Rockefeller University in the United States that later supported the first patent covering the direct use of DNA variation for forensic purposes.
1983
Jeffrey Glassberg filed the application that eventually led to the first patent covering the direct use of DNA variation for forensics.
1983
Kary Mullis developed the polymerase chain reaction, a technique that became central to amplifying small quantities of DNA for profiling.
Image source: Polymerase chain reaction
1984
British geneticist Sir Alec Jeffreys discovered DNA profiling in 1984 while working at the University of Leicester.
Image source: Alec Jeffreys
1984
Working in the Department of Genetics at the University of Leicester, Alec Jeffreys independently developed a process for DNA profiling.
1984
The DNA profiling process was developed for forensic use by Alec Jeffreys in conjunction with Peter Gill and Dave Werrett of the Forensic Science Service.
Image source: Forensic Science Service
1992 - 1996
Between 1992 and 1996, controversial arbitrary-low ceilings were imposed on match probabilities used in RFLP analysis instead of using higher theoretically computed probabilities.
1995
Researchers first reported in 1995 that smaller PCR products could achieve higher success with highly degraded samples, using miniSTR technology to identify victims of the Waco fire.
Image source: Microsatellite
1997
The first patent covering the direct use of DNA variation for forensics was issued in 1997, continuing from Jeffrey Glassberg's 1983 application and his earlier Rockefeller University work.
Image source: DNA profiling
Jul 7, 2008
On 7 July 2008, the American Chemical Society reported that Japanese chemists had created the world's first DNA molecule composed almost entirely of synthetic components.
Image source: Synthetic biology
1984
Darryl Hunt was wrongly convicted in connection with the rape and murder of a young woman in North Carolina, illustrating the importance of scrutinizing criminal identification evidence.
1988
The United States Supreme Court's decision in California v. Greenwood held that the Fourth Amendment does not prohibit warrantless search and seizure of garbage left for collection outside a home's curtilage, a ruling often cited in DNA privacy cases.
Image source: California v. Greenwood
1994
After Anna Anderson's death, tissue stored at a Charlottesville hospital was tested to examine her claim that she was Grand Duchess Anastasia Nikolaevna of Russia.
Image source: Anna Anderson
1994
DNA evidence led Virginia to commute Earl Washington Jr.'s death sentence to life imprisonment one week before his scheduled execution.
1998
A man residing in the United Kingdom was arrested on accusation of burglary, forming part of the history of controversies surrounding the interpretation and use of forensic DNA profiles.
1999
Raymond Easton, a disabled man from Swindon, England, was arrested and detained for seven hours in connection with a burglary because crime-scene DNA appeared to match him.
2000
DNA profiling proved Frank Lee Smith innocent of murdering an eight-year-old girl after he had spent 14 years on Florida's death row.
Image source: Eddie Mosley
2000
More advanced DNA testing led to a full pardon for Earl Washington Jr., whose death sentence had earlier been commuted on the basis of DNA evidence.
May 2000
Gordon Graham murdered Paul Gault at Gault's home in Lisburn, Northern Ireland; the case later featured in the development of DNA-supported criminal investigations.
2001
Wayne Butler was convicted for the murder of Celia Douty in a case included in the expanding use of DNA evidence in criminal investigations.
2002
The body of James Hanratty, hanged in 1962 for the A6 murder, was exhumed in 2002. DNA samples from his remains and family members were analyzed.
Aug 2002
Annalisa Vicentini was shot dead in Tuscany in August 2002, an event connected to a subsequent cross-border DNA investigation.
Mar 2003
Bartender Peter Hamkin was arrested in Merseyside on an extradition warrant and appeared at Bow Street Magistrates' Court over whether he should be taken to Italy to face a murder charge.
Jun 2003
New DNA evidence enabled Dennis Halstead, John Kogut and John Restivo to win a retrial in June 2003. Their 1986 murder convictions were struck down and they were released.
2004
DNA testing shed new light on the mysterious 1912 disappearance of four-year-old Bobby Dunbar. Tests on his son and nephew showed they were not related, establishing that the boy found in 1912 was not Bobby.
Image source: Disappearance of Bobby Dunbar
2004
The United Kingdom's Human Tissue Act 2004 prohibited private individuals from covertly collecting biological samples such as hair and fingernails for DNA analysis, while exempting medical and criminal investigations.
Image source: Human Tissue Act 2004
2005
Gary Leiterman was convicted of the 1969 murder of University of Michigan law student Jane Mixer after DNA from her pantyhose was matched to him.
Image source: Michigan Murders
2005
DNA from a drop of blood on Jane Mixer's hand was matched to John Ruelas, who had been only four years old in 1969 and was never otherwise successfully connected to the case.
Nov 2008
Anthony Curcio was arrested for masterminding one of the most elaborately planned armored-car heists in history, with DNA evidence contributing to the investigation.
Mar 2009
Sean Hodgson, convicted of killing Teresa De Simone in 1979, was released in March 2009 after testing proved that DNA from the crime scene was not his.
Aug 2009
Scientists in Israel raised serious doubts about relying on DNA as law enforcement's ultimate method of identification.
2012
Part 1 of the United Kingdom's Protection of Freedoms Act 2012 required DNA samples to be deleted when suspects were acquitted or not charged, subject to exceptions for certain mostly serious or sexual offenses.
2013
In Maryland v. King, the United States Supreme Court ruled that DNA sampling of prisoners arrested for serious crimes is constitutional.
Image source: Maryland v. King
2014
In 2014, Congress extended a bill intended to help United States states deal with a backlog of forensic evidence.
2015
In X and Anor v Z (Children) and Anor, the Court of Appeal for England and Wales decided that a DNA profile created by police during a criminal investigation could not lawfully be used for a paternity test.
2016
Anthea Ring, who had been abandoned as a baby, used a DNA sample and a DNA matching database to discover her deceased mother's identity and her roots in County Mayo, Ireland.
Image source: Genetic genealogy
2018
Using the Next Generation Identification System's enhanced biometric capabilities, the FBI matched a fingerprint belonging to Timothy David Nelson and arrested him 20 years after an alleged sexual assault.
1986
Richard Buckland was exonerated despite having confessed to the rape and murder of a teenager near Leicester, demonstrating DNA profiling's ability to overturn an apparent confession.
1987
Genetic fingerprinting was used in a United States criminal court for the first time in the trial of a man accused of unlawful intercourse with a mentally disabled 14-year-old girl who gave birth to a baby.
Nov 6, 1987
Florida rapist Tommie Lee Andrews became the first person in the United States convicted as a result of DNA evidence. He was convicted of raping a woman during a burglary and sentenced to 22 years in prison.
Image source: DNA profiling
1988
Led by Detective David Baker, the investigation obtained voluntary blood samples from about 5,000 local men. The results exonerated initial suspect Richard Buckland and helped secure Colin Pitchfork's conviction.
Jan 2, 1988
Colin Pitchfork was convicted in the Narborough murders after DNA profiling helped identify him through a large voluntary blood-sample investigation.
Image source: Colin Pitchfork
1990
The murder of a young student in Brno became the first criminal case in Czechoslovakia solved by DNA evidence; the murderer received a 23-year prison sentence.
1992
DNA obtained from a palo verde tree was used as evidence to convict Mark Alan Bogan of murder.
1996 - 1999
Kevin W. P. Miller and John L. Dawson at the University of Cambridge compiled an early mitochondrial DNA concordance from data collected for Miller's PhD thesis.
Image source: Mitochondrial DNA
2000
The Y haplotype reference database, or YHRD, was created as an online resource for Y-chromosome haplotype information.
Image source: Y Chromosome Haplotype Reference Database
2002
South Wales police used familial DNA matching to identify Joseph William Kappen as a triple killer, although he had died 11 years earlier.
2003
Crime-scene evidence from the 1988 Lynette White murder was re-examined using STR techniques and matched to Jeffrey Gafoor's nephew, who was 14 years old when the evidence was re-examined.
Jul 4, 2003
Familial DNA database searching was first used in an investigation leading to a conviction in the case of Jeffrey Gafoor, who was convicted of murdering Lynette White.
2004
Familial DNA searching was used again in 2004 to find a man who threw a brick from a motorway bridge and killed a lorry driver.
2008
Denver, Colorado, conducted the first familial DNA search in the United States that led to a subsequent conviction, using software developed under the leadership of Mitch Morrissey and Gregg LaBerge.
2008
Familial DNA later led to the arrest of 21-year-old Elvis Garcia on charges of sexual assault and false imprisonment of a woman in Santa Cruz in 2008.
2010
Familial DNA searching helped catch the Los Angeles serial killer known as the Grim Sleeper.
Image source: Grim Sleeper
2011
As of 2011, familial DNA database searching was not conducted nationally in the United States; individual states determined whether and how to conduct familial searches.
Mar 2011
Virginia Governor Bob McDonnell announced in March 2011 that Virginia would begin using familial DNA searches.
Mar 7, 2011
At a Virginia press conference on 7 March 2011, prosecutor Paul Ebert and detective John Kelly said the East Coast Rapist case would have been solved years earlier if Virginia had used familial DNA searching.
2018
The same genetic genealogist who assisted in the William Earl Talbott II case also helped police make 18 other arrests during 2018.
Image source: Investigative genetic genealogy
2018
Joseph James DeAngelo was arrested as the main suspect in the Golden State Killer case using DNA and genetic genealogy techniques.
Image source: Joseph James DeAngelo
2018
William Earl Talbott II was arrested as a suspect in the 1987 murders of Jay Cook and Tanya Van Cuylenborg with assistance from genealogical DNA testing.
May 2018
The United States maintained the world's largest DNA database, with the Combined DNA Index System holding more than 13 million records as of May 2018.
Image source: Combined DNA Index System
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