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350 BC
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Aristotle systematized observations and explanations of nature in works on physics, biology, astronomy, and logic. Although many conclusions were later rejected, his framework shaped scientific inquiry in Europe and the Islamic world for nearly two millennia.
Image source: Aristotle
300 BC
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Euclid compiled and proved a systematic body of geometry in Elements. Its axiomatic method became a foundational model for mathematics and influenced later approaches to rigorous scientific reasoning.
Image source: Euclid's Elements
250 BC
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Archimedes formulated principles of buoyancy and lever mechanics and made major advances in geometry and hydrostatics. His work connected mathematical deduction with the quantitative study of physical phenomena.
Image source: Archimedes
240 BC
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Using shadow measurements at two Egyptian locations, Eratosthenes estimated Earth's circumference with remarkable accuracy. His calculation demonstrated how geometry could determine large-scale properties of the planet.
Image source: Eratosthenes
105
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Papermaking was traditionally attributed to Cai Lun during the Han dynasty, although earlier paper-like materials existed. The technology eventually spread across Asia, the Islamic world, and Europe, transforming the circulation of scientific knowledge.
Image source: Paper
150
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Claudius Ptolemy's Almagest presented a mathematical geocentric model that predicted planetary positions. It synthesized Greek astronomical traditions and remained the dominant technical astronomy text for centuries.
Image source: Almagest
820
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Al-Khwarizmi's treatise on completing and balancing introduced systematic methods for solving equations. His work helped transmit Hindu-Arabic numerals and algebraic methods into later Islamic and European mathematics.
Image source: Al-Khwarizmi
1021
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In the Book of Optics, Ibn al-Haytham argued that vision occurs when light enters the eye and investigated reflection, refraction, and perception. His experiments and emphasis on testing explanations influenced later optical science.
Image source: Ibn al-Haytham
1543
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Nicolaus Copernicus's On the Revolutions of the Heavenly Spheres placed the Sun near the center of the planetary system. The proposal challenged the established Ptolemaic model and initiated a major transformation in astronomy.
Image source: Nicolaus Copernicus
1543
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Andreas Vesalius published detailed anatomical descriptions based on human dissections. His illustrated work corrected important Galenic errors and established direct observation as a central method in modern anatomy.
Image source: De Humani Corporis Fabrica Libri Septem
1600
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William Gilbert's De Magnete investigated magnetic materials and argued that Earth itself behaves like a giant magnet. The work helped separate experimental natural philosophy from older speculative traditions.
1609 - 1619
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Johannes Kepler derived three laws describing planetary orbits as ellipses, their changing speeds, and their orbital periods. His mathematical astronomy replaced circular planetary motion with a model that accurately matched observations.
Image source: Johannes Kepler
1609 - 1610
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Galileo used improved telescopes to observe mountains on the Moon, the phases of Venus, sunspots, and Jupiter's moons. These findings undermined important elements of Aristotelian cosmology and supported heliocentric astronomy.
Image source: Galileo Galilei
1620
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Francis Bacon's Novum Organum promoted systematic observation, experimentation, and collaborative investigation as means of overcoming intellectual biases. It became an influential statement of empiricism, though actual scientific practice developed through multiple traditions.
Image source: Novum Organum
1628
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William Harvey demonstrated that the heart pumps blood through a closed circulatory system. His quantitative arguments and anatomical observations overturned longstanding Galenic ideas about the movement of blood.
Image source: William Harvey
1687
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Isaac Newton's Principia formulated the laws of motion and universal gravitation and used them to explain terrestrial and celestial phenomena within one mathematical framework. It became a landmark of classical physics.
Image source: Philosophiæ Naturalis Principia Mathematica
1735
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Carl Linnaeus's Systema Naturae organized living organisms into nested groups and popularized binomial nomenclature. His system provided a durable language for naming species, even though later evolutionary biology revised its underlying assumptions.
Image source: Carl Linnaeus
1752
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Benjamin Franklin's electrical experiments, including the famous kite experiment, supported the identification of lightning as electrical. He also introduced influential terminology and helped establish the distinction between positive and negative charge.
Image source: Benjamin Franklin
1789
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Antoine Lavoisier's Elements of Chemistry presented a new chemical nomenclature and emphasized precise measurement. His work explained combustion through oxygen and helped displace the phlogiston theory.
Image source: Antoine Lavoisier
1796
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Edward Jenner demonstrated that inoculation with cowpox material could protect against smallpox. The practice became the foundation of vaccination and ultimately contributed to the global eradication of smallpox.
Image source: Edward Jenner
1803
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John Dalton proposed that elements consist of distinct atoms and that compounds form through combinations in fixed ratios. His theory gave chemistry a powerful quantitative framework, later refined by discoveries about subatomic structure.
Image source: John Dalton
1831
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Michael Faraday showed that changing magnetic fields induce electric currents. Electromagnetic induction became the operating principle of generators, transformers, and much of modern electrical technology.
Image source: Michael Faraday
1859
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Charles Darwin presented evolution by natural selection as an explanation for the diversity and adaptation of life. The book transformed biology by connecting variation, inheritance, competition, and common descent.
Image source: On the Origin of Species
1861 - 1885
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Louis Pasteur's experiments challenged spontaneous generation and linked microorganisms to fermentation and disease. His work supported germ theory, improved public health practices, and led to vaccines for several infections.
Image source: Louis Pasteur
1865
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James Clerk Maxwell's electromagnetic theory expressed electricity, magnetism, and light through a unified set of equations. It predicted electromagnetic waves and became a foundation of modern physics.
Image source: James Clerk Maxwell
1866
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Gregor Mendel reported experiments with pea plants showing that inherited traits are transmitted through discrete factors. Rediscovery of his work around 1900 helped establish genetics as a scientific discipline.
Image source: Gregor Mendel
1869
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Dmitri Mendeleev arranged known elements according to recurring chemical properties and atomic weights. He left gaps for undiscovered elements and successfully predicted several of their characteristics.
Image source: Dmitri Mendeleev
1895
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Wilhelm Röntgen discovered penetrating radiation that could create images of internal structures. X-rays rapidly transformed medical diagnosis and opened a new field of research into atomic and subatomic phenomena.
Image source: Wilhelm Röntgen
1897
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J. J. Thomson used cathode-ray experiments to demonstrate that atoms contain negatively charged particles smaller than atoms. The discovery of the electron challenged the idea that atoms were indivisible.
Image source: J. J. Thomson
1900
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Max Planck proposed that energy is emitted and absorbed in discrete packets to explain black-body radiation. This quantum hypothesis initiated the conceptual revolution that produced modern quantum physics.
Image source: Max Planck
1905
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Albert Einstein's special theory of relativity redefined space and time for objects moving at constant velocity and established the equivalence of mass and energy. It replaced Newtonian mechanics in the relativistic domain.
Image source: Special relativity
1912
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Alfred Wegener argued that continents had once formed a supercontinent and later moved apart. Although initially controversial because he lacked a mechanism, the idea became central to plate tectonics decades later.
Image source: Alfred Wegener
1915
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Albert Einstein's general theory of relativity described gravity as the curvature of spacetime produced by matter and energy. It predicted effects such as gravitational lensing and reshaped modern cosmology.
Image source: General relativity
1928
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Alexander Fleming observed that a mold inhibited bacterial growth and identified the substance as penicillin. Later development and mass production of the antibiotic inaugurated the antibiotic era.
Image source: Alexander Fleming
1929
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Edwin Hubble found a relationship between the distances of galaxies and their recession speeds. The observation provided strong evidence that the universe is expanding and became a foundation of modern cosmology.
Image source: Edwin Hubble
Apr 25, 1953
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James Watson and Francis Crick proposed the double-helix structure of DNA, drawing on crucial evidence from Rosalind Franklin, Maurice Wilkins, and others. The model explained how genetic information could be copied and helped launch molecular biology.
Image source: Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
Apr 14, 2003
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The Human Genome Project produced a reference sequence covering most of the human genome and identified thousands of genes. Its completion accelerated genomic medicine, comparative biology, and large-scale biological data analysis.
Image source: Human Genome Project
Jul 4, 2012
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Experiments at CERN's Large Hadron Collider announced evidence for the Higgs boson, the particle associated with the field that gives fundamental particles mass. The result completed a major prediction of the Standard Model of particle physics.
Image source: Higgs boson
1938
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Otto Hahn and Fritz Strassmann's experiments, interpreted by Lise Meitner and Otto Frisch, showed that uranium nuclei can split into smaller nuclei while releasing energy. The discovery transformed nuclear physics and energy technology.
Image source: Nuclear fission
Dec 2, 1942
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Enrico Fermi's team achieved the first controlled, self-sustaining nuclear chain reaction beneath the University of Chicago. The experiment demonstrated the feasibility of nuclear reactors and supported the wartime Manhattan Project.
Image source: Chicago Pile-1
Oct 4, 1957
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The Soviet Union launched Sputnik 1, the first artificial satellite. Its radio signals demonstrated the feasibility of orbital spaceflight and intensified international competition in science, engineering, and education.
Image source: Sputnik 1
Jul 20, 1969
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Apollo 11 astronauts Neil Armstrong and Buzz Aldrin became the first humans to walk on the Moon while Michael Collins orbited above. The mission represented a major achievement in rocketry, navigation, computing, and space science.
Image source: Apollo 11
Apr 10, 2019
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The Event Horizon Telescope collaboration released the first image of a black hole's shadow, observing the supermassive object at the center of galaxy M87. The result tested general relativity in an extreme gravitational environment.
Image source: Event Horizon Telescope
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