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The history of vitamins traces how scientists identified essential micronutrients, connected them to deficiency diseases, developed methods to isolate and synthesize them, and introduced fortification and supplements that transformed public health. More Less
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1747
Scottish surgeon James Lind discovered that citrus foods helped prevent scurvy, a disease involving impaired collagen formation, poor wound healing, bleeding gums, severe pain, and death. Portuguese and Spanish sailors had independently observed that oranges and vegetables such as yams and turnips reduced the disease.
Image source: James Lind
1753
James Lind published A Treatise of the Scurvy, recommending lemons and limes to prevent the disease. His recommendations were adopted by the British Royal Navy.
Image source: Scurvy
1800 - 1899
During the nineteenth century, limes grown in the West Indies were substituted for lemons in maritime practice. They were later found to contain much less vitamin C, contributing to continued scurvy and other deficiency diseases during Arctic expeditions.
Image source: Scurvy
1881
Russian medical doctor Nikolai Lunin studied the effects of scurvy at the University of Tartu, contributing to the developing investigation of diet-related disease.
1884
Takaki Kanehiro, a British-trained physician in the Imperial Japanese Navy, observed that beriberi was common among low-ranking crew members who often ate only rice, but not among officers who consumed a Western-style diet.
Image source: Takaki Kanehiro
1897
Christiaan Eijkman found that feeding chickens unpolished rice instead of polished rice prevented a form of polyneuritis equivalent to beriberi. The experiment strengthened the idea that diseases could result from dietary deficiencies.
Image source: Christiaan Eijkman
1901 - 1913
When Robert Falcon Scott undertook his two Antarctic expeditions in the early twentieth century, the prevailing medical theory attributed scurvy to tainted canned food rather than to a dietary deficiency.
Image source: Robert Falcon Scott
1905
Cornelis Adrianus Pekelharing reported a similar result in the Dutch medical journal Nederlands Tijdschrift voor Geneeskunde. The finding was not widely reported at the time.
Image source: Cornelis Adrianus Pekelharing
1910
Japanese scientist Umetaro Suzuki isolated a water-soluble complex of micronutrients from rice bran. He named it aberic acid, later called Orizanin.
Image source: Umetaro Suzuki
1910 - 1948
The vitamins were discovered during the period from 1910 through 1948, as nutritional research identified previously unknown micronutrients associated with the prevention of deficiency diseases.
Image source: Vitamin
1912
The term vitamin originated from vitamine, a portmanteau of vital amine coined by Casimir Funk and his friend Max Nierenstein while Funk was working at the Lister Institute of Preventive Medicine.
1912
Working in London, Polish-born biochemist Casimir Funk isolated the same general complex of micronutrients and proposed the name vitamine. Although he described it as an anti-beriberi factor, the substance was later associated with vitamin B3, while the anti-beriberi factor is now identified with thiamine, or vitamin B1.
Image source: Casimir Funk
1920
Jack Cecil Drummond proposed dropping the final e from vitamine to form vitamin, because researchers increasingly suspected that not all vitamins, especially vitamin A, contained an amine component.
1930
Paul Karrer elucidated the correct structure of beta-carotene, the main precursor of vitamin A, and identified other carotenoids.
Image source: Paul Karrer
1931
Albert Szent-Györgyi and Joseph Svirbely suspected that hexuronic acid was vitamin C. They gave a sample to Charles Glen King, who demonstrated its ability to counter scurvy using his established guinea-pig assay.
Image source: Albert Szent-Györgyi
1928
Adolf Windaus received the Nobel Prize in Chemistry for studies of the constitution of sterols and their connection with vitamins. He was the first Nobel laureate whose award citation mentioned vitamins, although the prize was not specifically for vitamin D.
Image source: Adolf Windaus
1929
Christiaan Eijkman and Frederick Gowland Hopkins were awarded the Nobel Prize in Physiology or Medicine for their contributions to the discovery of vitamins.
Image source: List of Nobel laureates in Physiology or Medicine
1934
George Whipple, George Minot, and William P. Murphy received the 1934 Nobel Prize in Physiology or Medicine for work directly or indirectly related to vitamin B12.
Image source: Vitamin B12
1937
For investigations of carotenoids, flavins, and vitamins A and B2, Paul Karrer and Richard Kuhn received the 1937 Nobel Prize in Chemistry.
Image source: List of Nobel laureates in Chemistry
1937
Albert Szent-Györgyi was awarded the Nobel Prize in Physiology or Medicine for his discovery connected with vitamin C.
1938
Richard Kuhn received the Nobel Prize in Chemistry for his work on carotenoids and vitamins, specifically vitamins B2 and B6.
Image source: Richard Kuhn
1943
Henrik Dam and Edward Adelbert Doisy were awarded the Nobel Prize in Physiology or Medicine for the discovery of vitamin K and its chemical structure.
1957
Alexander R. Todd was among the five people identified as Nobel laureates for direct or indirect studies of vitamin B12; he received the Nobel Prize in Chemistry in 1957.
Image source: Alexander R. Todd
1964
Dorothy Hodgkin was among the Nobel laureates recognized for direct or indirect studies of vitamin B12, receiving the Nobel Prize in Chemistry in 1964.
Image source: Dorothy Hodgkin
1967
George Wald, Ragnar Granit, and Haldan Keffer Hartline received the Nobel Prize in Physiology or Medicine for discoveries concerning the primary physiological and chemical visual processes in the eye. Wald’s contribution included discovering vitamin A’s role in vision.
Image source: George Wald
1935
Commercially produced tablets of yeast-extract vitamin B complex and semisynthetic vitamin C became available beginning in 1935.
1942
Robert W. Yoder is credited with first using the term vitamania to describe the appeal of relying on nutritional supplements instead of obtaining vitamins from a varied diet.
Image source: Dietary supplement
1942
When flour enrichment with nicotinic acid began, a popular headline called it tobacco in your bread. In response, the Council on Foods and Nutrition of the American Medical Association approved the names niacin and niacinamide for use primarily by nonscientists.
Image source: Nicotinic acid
1994
In the United States, the Dietary Supplement Health and Education Act of 1994 established the legal definition of a dietary supplement.
Image source: Dietary Supplement Health and Education Act of 1994
1994
Under the U.S. regulatory framework, there is no FDA approval process for dietary supplements and manufacturers are not required to prove the safety or efficacy of supplements introduced before 1994.
1997 - 2004
For the U.S. nutrient values cited in the source material, all data except calcium and vitamin D date from 1997 through 2004.
Image source: Dietary Reference Intake
2003 - 2006
A U.S. national food and supplement survey conducted from 2003 to 2006 found that more than 90 percent of individuals who did not consume vitamin supplements had inadequate levels of some essential vitamins, notably vitamins D and E. A varied diet generally makes severe primary deficiency unlikely, although intake can remain below recommended amounts.
Image source: Vitamin deficiency
2007
In 2007, Title 21, part III of the U.S. Code of Federal Regulations took effect, regulating good manufacturing practices for the manufacturing, packaging, labeling, and holding of dietary supplements.
2016
The American Association of Poison Control Centers recorded 63,931 overdose exposures involving all vitamin and multivitamin/mineral formulations in 2016. Children under five accounted for 72 percent of these exposures.
2018
A 2018 meta-analysis found no evidence that vitamin D or calcium intake reduced bone fractures among community-dwelling elderly people.
Image source: Vitamin D
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